Shugoshin anticorps (AA 339-367)

N° du produit ABIN1538328

Détail du produit anti-Shugoshin anticorps

Antigène: Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

Épitope: AA 339-367

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Shugoshin est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SGOL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 339-367 amino acids from the Central region of human SGOL1.

Clone: RB36785

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: SGOL1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Détails sur Shugoshin

Antigène: Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

Autre désignation: SGOL1 (SGOL1 Produits)

Synonymes: anticorps sgo1, anticorps NY-BR-85, anticorps SGO, anticorps Sgo1, anticorps 3300001M08Rik, anticorps C81037, anticorps shugoshin 1, anticorps shugoshin centromeric cohesion 1, anticorps shugoshin 1 L homeolog, anticorps Sgo1, anticorps sgo1, anticorps sgo1.L, anticorps SGO1

Sujet: SGOL1 plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.

Poids moléculaire: 64190

ID gène: 151648

NCBI Accession: NP_001012409, NP_001012410, NP_001012411, NP_001012412, NP_001012413, NP_001186180, NP_001186181, NP_001186182, NP_001186183, NP_001186184, NP_001186185, NP_001186186, NP_612493

UniProt: Q5FBB7

Pathways: Maintenance of Protein Location