WDR77 anticorps (C-Term)

N° du produit ABIN1574092

Détail du produit anti-WDR77 anticorps

Antigène: WDR77 (WD Repeat Domain 77 (WDR77))

Épitope: C-Term

Reactivité: Humain, Orang-Utan

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WDR77 est non-conjugé

Application: ELISA, Western Blotting (WB)

Specificité: Rabbit Anti-MEP50 Polyclonal Antibody detects endogenous levels of human MEP50 protein. It is predicted to react with sumatran orangutan MEP50 protein according to sequence homology.

Réactivité croisée (Details): Rabbit Anti-MEP50 Polyclonal Antibody detects endogenous levels of human MEP50 protein. It is predicted to react with sumatran orangutan MEP50 protein according to sequence homology.

Purification: Immunoaffinity chromatography

Immunogène: KLH-coupled synthetic peptide from carboxyl terminal of human MEP50

Isotype: IgG

Information d'application

Indications d'application: Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.

ELISA: 0.05-0.2 µg/mL
Western blot: 1-2 µg/mLOther Applications: user-optimized

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4, containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C/-20 °C

Stockage commentaire: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Détails sur WDR77

Antigène: WDR77 (WD Repeat Domain 77 (WDR77))

Autre désignation: MEP50 (WDR77 Produits)

Synonymes: anticorps MEP-50, anticorps MEP50, anticorps Nbla10071, anticorps RP11-552M11.3, anticorps p44, anticorps p44/Mep50, anticorps 2610003I18Rik, anticorps 2610312E17Rik, anticorps C79984, anticorps p44/MEP50, anticorps RGD1310479, anticorps mep50, anticorps valois, anticorps WDR77, anticorps zgc:65780, anticorps zgc:77274, anticorps WD repeat domain 77, anticorps WD repeat domain 77 S homeolog, anticorps WDR77, anticorps Wdr77, anticorps wdr77.S, anticorps wdr77

Sujet: MEP50 (methylosome protein 50), also known as WDR77, is a component of protein arginine methyltransferase complex containing at least PRMT5, CLNS1A and MEP50. It binds histone H2A selectively among core histones, and mediates transcriptional repression of protein arginine methyltransferase PRMT5. MEP50 is a WD repeat protein which interacts with an arginine protein JBP1. MEP50 plays a critical role in methylosome activity and may regulate the transfer of Sm proteins to the SMN (survival of motor neurons) complex, an early step in the assembly of U snRNPs. In addition, MEP50 may function to mediate the interaction of multiple substrates in the methylosome.Rabbit Anti-MEP50 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from carboxyl terminal of human MEP50. (Swiss Prot: Q9BQA1).

Pathways: Ribonucleoprotein Complex Subunit Organization