Metabotropic Glutamate Receptor 5 anticorps (C-Term)

N° du produit ABIN1574147

Détail du produit anti-Metabotropic Glutamate Receptor 5 anticorps

Antigène: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Épitope: C-Term

Reactivité: Rat, Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 5 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificité: Rabbit Anti-mGluR5 Polyclonal Antibody detects endogenous levels of human mGluR5. It is predicted to react with mouse and rat mGluR5 protein according to sequence homology.Positive Control: Ramos

Réactivité croisée (Details): Rabbit Anti-mGluR5 Polyclonal Antibody detects endogenous levels of human mGluR5. It is predicted to react with mouse and rat mGluR5 protein according to sequence homology.Positive Control: Ramos

Purification: Immunoaffinity chromatography

Immunogène: KLH-coupled synthetic peptide from C-terminal of human mGluR5

Isotype: IgG

Information d'application

Indications d'application: Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Western blot: 1-2 µg/mLFlow cytometry: 1-3 µg for 1 x 106 cellsOther applications: user-optimized

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4, containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C/-20 °C

Stockage commentaire: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Détails sur Metabotropic Glutamate Receptor 5

Antigène: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Autre désignation: mGluR5 (GRM5 Produits)

Synonymes: anticorps GPRC1E, anticorps MGLUR5, anticorps mGlu5, anticorps mGluR5, anticorps mGlur5, anticorps 6430542K11Rik, anticorps AI850523, anticorps Glu5R, anticorps Gprc1e, anticorps mGluR5b, anticorps glutamate receptor, metabotropic 5, anticorps glutamate metabotropic receptor 5, anticorps GRM5, anticorps Grm5

Sujet: Metabotropic glutamate receptor 5 (mGluR5) is one member of G-protein coupled receptor 3 family. The activity of mGluR5 receptor is mediated by a G-protein that activates phosphatidylinositol-calcium second messenger system and generates calcium-activated chloride current. mGluR5 plays a critical role in the modulation of synaptic plasticity and behavioral responses to multiple substances of abuse. The expression of mGluR5 is widely distributed in brain regions relating to memory, such as the hippocampus. mGluR5 regulates phospholipid hydrolysis in developing cortical neurons through the activation of PLC-beta1. The receptor regulates glutamatergic transmission in a variety of brain regions, particularly those thought to participate in reward-related behaviors. Its activation by the group I mGluR agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) can induce long term depression (DHPG-LTD) of glutamatergic synaptic transmission.Rabbit Anti-mGluR5 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human mGluR5 (Swiss Prot: P41594).

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity