VEGFC anticorps

N° du produit ABIN1589911

Détail du produit anti-VEGFC anticorps

Antigène: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VEGFC est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: VEGF-C antibody

Specificité: Recombinant rat VEGF-C

Attributs du produit: Chromosomal location: 16p11
Produced from sera of rabbits immunized with highly pure recombinant rat dNdC-VEGF-C.

Purification: Anti-rat VEGF-C IgG was purified by affinity chromatography with immobilized Protein A.

Immunogène: Recombinant rat VEGF-C (ABIN1589785)

Isotype: IgG

Information d'application

Indications d'application: Western Blot: Use 2-5 μg/mL

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Conseil sur la manipulation: Centrifuge vial prior to opening.

Stock: 4 °C,-20 °C

Stockage commentaire: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Date de péremption: 24 months

Références pour anticorps anti-VEGFC (ABIN1589911)

Maertens, Erpicum, Detry, Blacher, Lenoir, Carnet, Péqueux, Cataldo, Lecomte, Paupert, Noel: "Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis." dans: PLoS ONE, Vol. 9, Issue 9, pp. e106976, (2014) (PubMed).

Détails sur VEGFC

Antigène: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Autre désignation: VEGF-C (VEGFC Produits)

Synonymes: anticorps VEGFC, anticorps vegf-c, anticorps xvegf-c, anticorps Flt4-L, anticorps VRP, anticorps AW228853, anticorps VEGF-C, anticorps vascular endothelial growth factor c, anticorps vascular endothelial growth factor C, anticorps vascular endothelial growth factor C S homeolog, anticorps vegfc, anticorps VEGFC, anticorps vegfc.S, anticorps Vegfc

Sujet: Vascular endothelial growth factor C, Vegfc,VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant, fully processed rat VEGF-C is a 16-18 kDa non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.

ID gène: 114111

NCBI Accession: NM_053653, NP_446105

UniProt: O35757

Pathways: Signalisation RTK, Signaling Events mediated by VEGFR1 and VEGFR2