MESP1 anticorps

N° du produit ABIN1589957

Détail du produit anti-MESP1 anticorps

Antigène: MESP1 (Mesoderm Posterior 1 (MESP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MESP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Fonction: MesP1 antibody

Specificité: Recombinant human MesP1

Attributs du produit: Chromosomal location: 15q26.1

Purification: Protein A purified

Immunogène: Recombinant human MesP1

Isotype: IgG

Information d'application

Indications d'application: Western Blot: Use 1-5 μg/mL

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Conseil sur la manipulation: Centrifuge vial prior to opening.

Stock: 4 °C,-20 °C

Stockage commentaire: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Date de péremption: 24 months

Détails sur MESP1

Antigène: MESP1 (Mesoderm Posterior 1 (MESP1))

Autre désignation: MesP1 (MESP1 Produits)

Synonymes: anticorps bHLHc5, anticorps mesp, anticorps mesp1, anticorps mespa, anticorps CMESO-1, anticorps CMESO2, anticorps MESP1, anticorps mesoderm posterior 1, anticorps mesoderm posterior bHLH transcription factor 1, anticorps mesoderm posterior 1 homolog (mouse), anticorps mesoderm posterior homolog B, anticorps mesoderm posterior homolog B L homeolog, anticorps Mesp1, anticorps MESP1, anticorps mesp1, anticorps mespb, anticorps mespb.L

Sujet: MESP1, bHLHc5,ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardiovascular precursors and is required for cardiac morphogenesis. It was shown that MesP1 is a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells. Electrophysiological analysis showed all subtypes of cardiac ES-cell differentiation. MesP1 overexpression and knockdown experiments revealed a prominent function of MesP1 in a gene regulatory cascade, causing Dkk-1-mediated blockade of canonical Wnt-signalling. Independent evidence from ChIP and in vitro DNA-binding studies, expression analysis in wild-type and MesP knockout mice, and reporter assays confirm that Dkk-1 is a direct target of MesP1.

ID gène: 55897

NCBI Accession: NM_018670, NP_061140

UniProt: Q9BRJ9

Pathways: Regulation of Muscle Cell Differentiation