PEG10 anticorps (AA 1-325)

N° du produit ABIN1681320

Détail du produit anti-PEG10 anticorps

Antigène: PEG10 (Paternally Expressed 10 (PEG10))

Épitope: AA 1-325

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PEG10 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: MTERRRDELS EEINNLREKV MKQSEENNNL QSQVQKLTEE NTTLREQVEP TPEDEDDDIE LRGAAAAAAP PPPIEEECPE DLPEKFDGNP DMLAPFMAQC QIFMEKSTRD FSVDRVRVCF VTSMMTGRAA RWASAKLERS HYLMHNYPAF MMEMKHVFED PQRREVAKRK IRRLRQGMGS VIDYSNAFQM IAQDLDWNEP ALIDQYHEGL SDHIQEELSH LEVAKSLSAL IGQCIHIERR LARAAAARKP RSPPRALVLP HIASHHQVDP TEPVGGARMR LTQEEKERRR KLNLCLYCGT GGHYADNCPA KASKSSPAGN SPAPL

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human PEG10 (NP_001035242.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PEG10

Antigène: PEG10 (Paternally Expressed 10 (PEG10))

Autre désignation: PEG10 (PEG10 Produits)

Synonymes: anticorps EDR, anticorps HB-1, anticorps MEF3L, anticorps Mar2, anticorps Mart2, anticorps RGAG3, anticorps AA407948, anticorps Edr, anticorps MyEF-3, anticorps paternally expressed 10, anticorps PEG10, anticorps Peg10

Sujet: This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1, and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene.,PEG10,EDR,HB-1,MEF3L,Mar2,Mart2,RGAG3,RTL2,SIRH1,Epigenetics & Nuclear Signaling,Transcription Factors,RNA Binding,Cancer,Stem Cells,Germline Stem Cells,PEG10

Poids moléculaire: 36 kDa/80 kDa

ID gène: 23089

UniProt: Q86TG7