LAIR1 anticorps

N° du produit ABIN1690731

Détail du produit anti-LAIR1 anticorps

Antigène: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LAIR1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Specificité: The mouse monoclonal antibody NKTA255 recognizes an extracellular epitope of CD305 / LAIR1, a 40 kDa type I transmembrane glycoprotein expressed on NK, T, and B cells, monocytes, dendritic cells, eosinophils, basophils, mast cells, CD34+ hematopoietic progenitor cells and thymocytes.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Activated NK cells and CD3- thymocytes

Clone: NKTA255

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-LAIR1 (ABIN1690731)

Colombo, Canevali, Magnani, Rossi, Puppo, Zocchi, Poggi: "Defective expression and function of the leukocyte associated Ig-like receptor 1 in B lymphocytes from systemic lupus erythematosus patients." dans: PLoS ONE, Vol. 7, Issue 2, pp. e31903, (2012) (PubMed).

Son, Santiago-Schwarz, Al-Abed, Diamond: "C1q limits dendritic cell differentiation and activation by engaging LAIR-1." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 46, pp. E3160-7, (2012) (PubMed).

Meyaard: "The inhibitory collagen receptor LAIR-1 (CD305)." dans: Journal of leukocyte biology, Vol. 83, Issue 4, pp. 799-803, (2008) (PubMed).

Warren: "The Eighth Human Leucocyte Differentiation Antigen (HLDA8) Workshop: natural killer cell section report." dans: Cellular immunology, Vol. 236, Issue 1-2, pp. 17-20, (2005) (PubMed).

Poggi, Tomasello, Ferrero, Zocchi, Moretta: "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor." dans: European journal of immunology, Vol. 28, Issue 7, pp. 2086-91, (1998) (PubMed).

Poggi, Tomasello, Revello, Nanni, Costa, Moretta: "p40 molecule regulates NK cell activation mediated by NK receptors for HLA class I antigens and TCR-mediated triggering of T lymphocytes." dans: International immunology, Vol. 9, Issue 9, pp. 1271-9, (1997) (PubMed).

Détails sur LAIR1

Antigène: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Autre désignation: CD305 / LAIR1 (LAIR1 Produits)

Synonymes: anticorps 5133400O11Rik, anticorps BB115266, anticorps D7Bwg0421e, anticorps Lair-1, anticorps mLair-1, anticorps CD305, anticorps LAIR-1, anticorps leukocyte-associated Ig-like receptor 1, anticorps leukocyte associated immunoglobulin like receptor 1, anticorps leukocyte-associated immunoglobulin-like receptor 1, anticorps Lair1, anticorps LAIR1

Sujet: Leukocyte associated immunoglobulin like receptor,CD305, also known as LAIR1 (leukocyte-associated Ig-like receptor 1), is an inhibitory receptor found on many types of peripheral blood cells. It serves to suppress cell cytotoxicity, activation, proliferation, and differentiation regarding autoantigens via its two intracellular ITIM sites. CD305 belongs to the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family of proteins. It reacts with collagen ligands.,LAIR1

ID gène: 3903

UniProt: Q6GTX8