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ENPP3 anticorps (APC)

ENPP3 Reactivité: Humain FACS Hôte: Souris Monoclonal NP4D6 APC
N° du produit ABIN1690741
  • Antigène Voir toutes ENPP3 Anticorps
    ENPP3 (Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3))
    Reactivité
    • 72
    • 34
    • 18
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 52
    • 20
    Souris
    Clonalité
    • 53
    • 19
    Monoclonal
    Conjugué
    • 23
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ENPP3 est conjugé à/à la APC
    Application
    • 33
    • 26
    • 26
    • 13
    • 13
    • 9
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody NP4D6 reacts with an extracellular epitope of CD203c, a transmembrane ectoenzyme expressed on basophils and mast cells, and overexpressed upon their activation.
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    HEK-293 cells transfected with human CD203c
    Clone
    NP4D6
    Isotype
    IgG1
    Top Product
    Discover our top product ENPP3 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Extracellular and intracellular staining.
    Commentaires

    The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Heneberg, Riegerová, Kučera: "Pimecrolimus Is a Potent Inhibitor of Allergic Reactions to Hymenopteran Venom Extracts and Birch Pollen Allergen In Vitro." dans: PLoS ONE, Vol. 10, Issue 11, pp. e0142953, (2015) (PubMed).

    Platz, Binder, Marxer, Lischka, Valent, Bühring: "Hymenoptera-venom-induced upregulation of the basophil activation marker ecto-nucleotide pyrophosphatase/phosphodiesterase 3 in sensitized individuals." dans: International archives of allergy and immunology, Vol. 126, Issue 4, pp. 335-42, (2002) (PubMed).

    Bühring, Seiffert, Giesert, Marxer, Kanz, Valent, Sano: "The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3." dans: Blood, Vol. 97, Issue 10, pp. 3303-5, (2001) (PubMed).

  • Antigène
    ENPP3 (Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3))
    Autre désignation
    CD203c (ENPP3 Produits)
    Synonymes
    anticorps B10, anticorps CD203c, anticorps NPP3, anticorps PD-IBETA, anticorps PDNP3, anticorps Npp3, anticorps RB13-6, anticorps AI876438, anticorps ENPP3, anticorps ectonucleotide pyrophosphatase/phosphodiesterase 3, anticorps ectonucleotide pyrophosphatase/phosphodiesterase 3 L homeolog, anticorps ENPP3, anticorps Enpp3, anticorps enpp3, anticorps enpp3.L
    Sujet
    Ectonucleotide pyrophosphatase/phosphodiesterase 3,CD203c, also known as ENPP-3, is integral membrane ectoenzyme (ectonucleotide pyrophosphatase/phosphodiesterase 3), that hydrolyses nucleotide triphosphates and thus modulates purinergic signaling. CD203c is expressed mainly on activated basophils and mast cells. CD203c is upregulated in response to IgE-receptor cross-linking and is overexpressed on neoplastic mast cells in patients with systemic mastocytosis. Measurement of its induced enhancement on the plasma membrane is useful for diagnostics of allergies.,ENPP3, B10, PDNP3, PD-IBETA
    ID gène
    5169
    UniProt
    O14638
    Pathways
    Regulation of Muscle Cell Differentiation, Negative Regulation of Transporter Activity
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