SOCS5 anticorps (AA 151-250) (AbBy Fluor® 488)
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- Antigène Voir toutes SOCS5 Anticorps
- SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))
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Épitope
- AA 151-250
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SOCS5 est conjugé à/à la AbBy Fluor® 488
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Cow,Sheep,Chicken
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human SOCS5
- Isotype
- IgG
- Top Product
- Discover our top product SOCS5 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))
- Autre désignation
- SOCS5 (SOCS5 Produits)
- Synonymes
- anticorps SOCS5, anticorps cis6, anticorps cish5, anticorps cish6, anticorps socs-5, anticorps GB18949, anticorps socs5, anticorps zgc:153506, anticorps CIS6, anticorps CISH6, anticorps Cish5, anticorps SOCS-5, anticorps 1810018L08Rik, anticorps mKIAA0671, anticorps RGD1564914, anticorps suppressor of cytokine signaling 5, anticorps suppressor of cytokine signaling 5a, anticorps suppressor of cytokine signaling 5 L homeolog, anticorps SOCS5, anticorps socs5, anticorps LOC552036, anticorps socs5a, anticorps Tsp_07018, anticorps socs5.L, anticorps Socs5
- Sujet
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Synonyms: CIS-6, CIS6, CISH5, CISH6, Cytokine inducible SH2 containing protein 5, Cytokine inducible SH2 protein 6, KIAA0671, SOCS-5, Suppressor of cytokine signaling 5.
Background: The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.
- Pathways
- Signalistation JAK/STAT, EGFR Signaling Pathway, Positive Regulation of Immune Effector Process
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