FRAT1 anticorps (AA 161-260) (AbBy Fluor® 488)
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- Antigène Voir toutes FRAT1 Anticorps
- FRAT1 (Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1))
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Épitope
- AA 161-260
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FRAT1 est conjugé à/à la AbBy Fluor® 488
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Homologie
- Human,Mouse,Rat,Dog,Cow
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human FRAT1
- Isotype
- IgG
- Top Product
- Discover our top product FRAT1 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- FRAT1 (Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1))
- Autre désignation
- FRAT1 (FRAT1 Produits)
- Synonymes
- anticorps FRAT1, anticorps frat1, anticorps AW060382, anticorps gbp, anticorps FRAT1, WNT signaling pathway regulator, anticorps GSK-3 binding protein FRAT1, anticorps frequently rearranged in advanced T cell lymphomas, anticorps frequently rearranged in advanced T-cell lymphomas, anticorps frequently rearranged in advanced T-cell lymphomas 1 S homeolog, anticorps FRAT1, anticorps frat1, anticorps Frat1, anticorps frat1.S
- Sujet
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Synonyms: FRAT 1, frequently rearranged in advanced T cell lymphomas, Frequently rearranged in advanced T-cell lymphomas, GSK 3 binding protein FRAT1, proto oncogene FRAT1, FRAT1_HUMAN.
Background: FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.
- ID gène
- 10023
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