APLF anticorps (AA 421-511) (AbBy Fluor® 555)
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- Antigène Voir toutes APLF Anticorps
- APLF (Aprataxin and PNKP Like Factor (APLF))
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Épitope
- AA 421-511
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp APLF est conjugé à/à la AbBy Fluor® 555
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Homologie
- Human,Mouse,Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human APLF
- Isotype
- IgG
- Top Product
- Discover our top product APLF Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- APLF (Aprataxin and PNKP Like Factor (APLF))
- Autre désignation
- APLF (APLF Produits)
- Synonymes
- anticorps apfl, anticorps palf, anticorps xip1, anticorps APLF, anticorps C2orf13, anticorps DKFZp459J1223, anticorps APFL, anticorps PALF, anticorps Xip1, anticorps 2010301N04Rik, anticorps AI452191, anticorps RGD1565557, anticorps aprataxin and PNKP like factor, anticorps APLF, anticorps aplf, anticorps Aplf
- Sujet
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Synonyms: 2010301N04Rik, AI452191, Aplf, APLF_HUMAN, Aprataxin and pnk-like factor, Apurinic-apyrimidinic endonuclease APLF, C2orf13, PNK and APTX like FHA protein, PNK and APTX-like FHA domain-containing protein, RGD1565557, XIP1, XRCC1 interacting protein 1, XRCC1-interacting protein 1.
Background: APLF is a 511 amino acid protein that contains one FHA doman and two C2H2type zinc fingers. Localized to both the nucleus and the cytoplasm, APLF interacts with XRCC1, XRCC4 and Ku-86 and, via these interactions, is involved in single-strand and double-strand DNA break repair. APLF is subject to post-translational phosphorylation in response to DNA breaks. The gene encoding APLF maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8 % of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.
- ID gène
- 200558
- Pathways
- Réparation de l'ADN
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