GEM anticorps (AA 201-296) (AbBy Fluor® 555)
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- Antigène Voir toutes GEM Anticorps
- GEM (GTP Binding Protein Overexpressed in Skeletal Muscle (GEM))
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Épitope
- AA 201-296
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GEM est conjugé à/à la AbBy Fluor® 555
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain
- Homologie
- Mouse,Rat,Dog,Cow,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human GEM
- Isotype
- IgG
- Top Product
- Discover our top product GEM Anticorps primaire
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- Indications d'application
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- GEM (GTP Binding Protein Overexpressed in Skeletal Muscle (GEM))
- Autre désignation
- GEM (GEM Produits)
- Synonymes
- anticorps KIR, anticorps GEM, anticorps DKFZp470D0612, anticorps LOC100221129, anticorps kir, anticorps xgem, anticorps zgc:153003, anticorps Gem, anticorps AV020497, anticorps GTP binding protein overexpressed in skeletal muscle, anticorps geminin, DNA replication inhibitor, anticorps GTP binding protein (gene overexpressed in skeletal muscle), anticorps GEM, anticorps gem, anticorps Gem, anticorps GMNN
- Sujet
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Synonyms: GTP binding mitogen induced T cell protein, GTP binding protein expressed in mitogen stimulated T cells, GTP binding protein GEM, GTP binding protein overexpressed in skeletal muscle, Kinase inducible Ras like protein, KIR, MGC26294, RAS like protein KIR, GEM_HUMAN.
Background: Gem belongs to the Rad/Gem/Kir (RGK) subfamily of Ras-related GTPases, which lack typical C-terminal amino acid motifs for isoprenylation. Rad and Gem bind calmodulin in a Ca2+-dependent manner via this C-terminal extension, involving residues 278297 in human Rad. High intracellular Gem levels, which interact with intact microtubules and microfilaments, promote profound changes in cell morphology. Ectopic Gem expression is sufficient to stimulate cell flattening and neurite extension in N1E-115 and SH-SY5Y neuroblastoma cells, suggesting a role for Gem in cytoskeletal rearrangement and/or morphological differentiation of neurons. Gem was also observed in developing trigeminal nerve ganglia in 12.5 day mouse embryos, demonstrating that Gem expression is a property of normal ganglionic development. The interaction of Gem with beta-subunits regulates Ca2+ channel expression at the cell surface. The human Gem gene maps to chromosome ,8q22.1.
- ID gène
- 2669
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