GMEB2 anticorps (AA 101-200) (AbBy Fluor® 647)
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- Antigène Voir toutes GMEB2 Anticorps
- GMEB2 (Glucocorticoid Modulatory Element Binding Protein 2 (GMEB2))
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Épitope
- AA 101-200
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Reactivité
- Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GMEB2 est conjugé à/à la AbBy Fluor® 647
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Souris
- Homologie
- Human,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human GMEB2
- Isotype
- IgG
- Top Product
- Discover our top product GMEB2 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- GMEB2 (Glucocorticoid Modulatory Element Binding Protein 2 (GMEB2))
- Autre désignation
- GMEB2 (GMEB2 Produits)
- Synonymes
- anticorps GMEB2, anticorps P79PIF, anticorps PIF79, anticorps AI839884, anticorps glucocorticoid modulatory element binding protein 2, anticorps glucocorticoid modulatory element binding protein 2 S homeolog, anticorps GMEB2, anticorps gmeb2.S, anticorps Gmeb2
- Sujet
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Synonyms: GMEB2, DNA binding protein p79P, DNA-binding protein p79P, Glucocorticoid modulatory element binding protein 2, Glucocorticoid modulatory element-binding protein 2, GMEB 2, GMEB-2, Gmeb2, GMEB2_HUMAN, KIAA1269, P79P, Parvovirus initiation factor p79, P p79, P79, RP4 663D7.1.
Background: GMEB-2 is a DNA-binding protein that plays a crucial role modulating transcription upon activation by steroid hormones. GMEB-2 is ubiquitously expressed with preferential expression in developmentally important tissues, such as testis, bone marrow, placenta and fetal tissues. It localizes to the nucleus and cytoplasm and contains a SAND domain near its N-terminus and a C-terminal coiled coil structure. GMEB-2 functions as a homodimer or as a heterodimer with GMEB-1. The formed complex specifically binds to glucocorticoid modulatory elements (GME) in the promoter region of target genes and recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling. This acts to increase sensitivity to low concentrations of glucocorticoids. In addition, GMEB-2 functions as an auxiliary factor required for parvovirus replication.
- ID gène
- 26205
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