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EXOSC10 anticorps (AA 41-140) (AbBy Fluor® 647)

EXOSC10 Reactivité: Humain, Souris WB, IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 647
N° du produit ABIN1699430
  • Antigène Voir toutes EXOSC10 Anticorps
    EXOSC10 (Exosome Component 10 (EXOSC10))
    Épitope
    • 14
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 41-140
    Reactivité
    • 34
    • 22
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 33
    • 2
    Lapin
    Clonalité
    • 33
    • 2
    Polyclonal
    Conjugué
    • 19
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp EXOSC10 est conjugé à/à la AbBy Fluor® 647
    Application
    • 30
    • 12
    • 12
    • 11
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris
    Homologie
    Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human EXOSC10/PMSCL2
    Isotype
    IgG
    Top Product
    Discover our top product EXOSC10 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    EXOSC10 (Exosome Component 10 (EXOSC10))
    Autre désignation
    EXOSC10/PMSCL2 (EXOSC10 Produits)
    Synonymes
    anticorps Pmscl2, anticorps zgc:55695, anticorps pm-scl, anticorps pm/scl-100, anticorps pmscl, anticorps pmscl2, anticorps rrp6, anticorps rrp6p, anticorps EXOSC10, anticorps 201.t00018, anticorps 21.m02990, anticorps DDBDRAFT_0203581, anticorps DDBDRAFT_0233752, anticorps DDB_0203581, anticorps DDB_0233752, anticorps PM-Scl, anticorps PM/Scl-100, anticorps PMSCL, anticorps PMSCL2, anticorps RRP6, anticorps Rrp6p, anticorps p2, anticorps p3, anticorps p4, anticorps exosome component 10, anticorps 3'-5' exonuclease, anticorps exosome component 10 L homeolog, anticorps exosc10, anticorps EXOSC10, anticorps EHI_021400, anticorps BBOV_IV002650, anticorps CpipJ_CPIJ003896, anticorps CMU_031760, anticorps Tsp_05247, anticorps exosc10.L, anticorps Exosc10
    Sujet

    Synonyms: Autoantigen PM/Scl 2, Exosc10, Exosome component 10, EXOSX_HUMAN, P100 polymyositis scleroderma overlap syndrome associated autoantigen, P100 polymyositis-scleroderma overlap syndrome-associated autoantigen, p2, p3, p4, PM Scl, PM/Scl 100, PM/Scl-100, PMSCL, PMSCL2, Polymyositis/scleroderma autoantigen 100 kDa, Polymyositis/scleroderma autoantigen 2 100 kDa, Polymyositis/scleroderma autoantigen 2, RRP6, Rrp6p.

    Background: The exosome is a multi-subunit complex composed of several highly conserved proteins, some of which are 3? to 5? exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3? region. EXOSC10, also known as PMSCL, PMSCL2, p2, p3, p4, RRP6, Rrp6p, PM-Scl, or PM/Scl-100, is an 885 amino acid protein that contains one HRDC domain and one 3?-5? enonuclease domain. Localized to both the cytoplasm and the nucleus, EXOSC10 is part of the post-splicing exosome complex and is involved in mRNA surveillance, mRNA nuclear export and nonsense-mediated decay of mRNAs containing premature stop codons. against EXOSC10 have been found in patients with scleroderma and/or polymyositis (chronic diseases of the skin and muscle, respectively), suggesting that EXOSC10 may be involved in the pathogenesis of these diseases. Two isoforms of EXOSC10 exist due to alternative splicing events.

    ID gène
    5394
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