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Hephaestin anticorps (AA 21-120) (AbBy Fluor® 647)

HEPH Reactivité: Humain, Souris WB, IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 647
N° du produit ABIN1699771
  • Antigène Voir toutes Hephaestin (HEPH) Anticorps
    Hephaestin (HEPH)
    Épitope
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 21-120
    Reactivité
    • 24
    • 18
    • 5
    Humain, Souris
    Hôte
    • 22
    • 3
    Lapin
    Clonalité
    • 24
    • 2
    Polyclonal
    Conjugué
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Hephaestin est conjugé à/à la AbBy Fluor® 647
    Application
    • 24
    • 12
    • 12
    • 10
    • 7
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris
    Homologie
    Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Hephaestin
    Isotype
    IgG
    Top Product
    Discover our top product HEPH Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Hephaestin (HEPH)
    Autre désignation
    Hephaestin (HEPH Produits)
    Synonymes
    anticorps HEPH, anticorps C130006F04Rik, anticorps Cpl, anticorps mKIAA0698, anticorps sla, anticorps CPL, anticorps hephaestin, anticorps HEPH, anticorps heph, anticorps Heph
    Sujet

    Synonyms: CPL, HEPH, HEPH_HUMAN, Hephaestin.

    Background: Hephaestin is a single-pass type I membrane protein that belongs to the multicopper oxidase family of proteins. Hephaestin, a copper-dependant ferroxidase protein, is crucial for iron exiting intestinal enterocytes into the circulation. It mediates the movement of iron across the basolateral membrane in conjunction with ferroportin 1. This is an important link between iron and copper metabolism in mammalian systems, as copper deficiency leads to reduced hephaestin and reduced iron absorption resulting in anemia. Hephaestin can bind six copper ions per monomer and is regulated by the homeobox transcription factor CDX2. Increased levels of iron leads to an increase in CDX2 expression and thus Hephaestin. Hephaestin is primarily detected in the intestine, but is also expressed in colon, breast, bone trabecural cells and fibroblasts.

    ID gène
    9843
    Pathways
    Transition Metal Ion Homeostasis
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