STAP2 anticorps (AA 151-250) (Biotin)

N° du produit ABIN1700074

Détail du produit anti-STAP2 anticorps (Biotin)

Antigène: STAP2 (Signal Transducing Adaptor Family Member 2 (STAP2))

Épitope: AA 151-250

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STAP2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human STAP2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur STAP2

Antigène: STAP2 (Signal Transducing Adaptor Family Member 2 (STAP2))

Autre désignation: STAP2 (STAP2 Produits)

Synonymes: anticorps BKS, anticorps AW049765, anticorps STAP-2, anticorps wu:fa55b07, anticorps zgc:77021, anticorps cb901, anticorps stap2, anticorps wu:fd15d07, anticorps zgc:63913, anticorps signal transducing adaptor family member 2, anticorps signal transducing adaptor family member 2b, anticorps signal transducing adaptor family member 2a, anticorps STAP2, anticorps Stap2, anticorps stap2b, anticorps stap2a

Sujet:

Synonyms: BKS, Breast tumor kinase substrate, BRK substrate, Signal transducing adaptor protein 2, Signal-transducing adaptor protein 2, Ssignal transducing adaptor family member 2, STAP 2, STAP-2, STAP2, STAP2_HUMAN.

Background: Protein kinases comprise a large group of encoded factors that regulate cellular processes by catalyzing the transfer of a phosphate group to a hydroxyl acceptor in serine, threonine or tyrosine residues (1,2). Kinases are capable of influencing the oncogenic potential of cell sytems at the level of oncoprotein or tumor suppressor protein phosphorylation states (1,2). STAP-2 is a protein that contains a pleckstrin homology (PH) domain and an SH2 domain, and associates with BRK (3). BRK (breast tumor kinase, Sik) is a 451 amino acid, nonreceptor protein-tyrosine kinase that is overexpressed in breast tumors and metastatic melanoma cell lines (4). Similar to the Src family of intracellular kinses, BRK is comprised of an SH3 domain, an SH2 domain, and a catalytic domain (5). STAP-2 is susceptiple to tyrosine phosphorylation and may be invovled in tyrosine kinase-mediated signaling cascades, whose aberrant function may lead to metastis (3).

ID gène: 55620

UniProt: Q9UGK3