POLH anticorps (AA 51-160) (Biotin)

N° du produit ABIN1700262

Détail du produit anti-POLH anticorps (Biotin)

Antigène: POLH (Polymerase (DNA Directed), eta (POLH))

Épitope: AA 51-160

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLH est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human DNA polymerase eta

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur POLH

Antigène: POLH (Polymerase (DNA Directed), eta (POLH))

Autre désignation: DNA polymerase eta (POLH Produits)

Synonymes: anticorps POLH, anticorps fc50a12, anticorps wu:fc50a12, anticorps zgc:136881, anticorps zgc:152642, anticorps RAD30, anticorps RAD30A, anticorps XP-V, anticorps XPV, anticorps polymerase (DNA directed), eta S homeolog, anticorps DNA polymerase eta, anticorps polymerase (DNA directed), eta, anticorps putative DNA polymerase eta, anticorps polymerase (DNA directed), eta (RAD 30 related), anticorps polh.S, anticorps POLH, anticorps polh, anticorps Tb10.70.6190, anticorps LINJ_21_0690, anticorps Polh, anticorps LOC100443019

Sujet:

Synonyms: DNA polymerase eta, FLJ16395, FLJ21978, POLH, POLH_HUMAN, polymerase DNA directed eta, RAD30, RAD30 homolog A, RAD30A, Xeroderma pigmentosum variant type protein, XP V, XPV.

Background: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.

ID gène: 5429

Pathways: Réparation de l'ADN