NGEF anticorps (pTyr179) (Biotin)

N° du produit ABIN1700479

Détail du produit anti-NGEF anticorps (Biotin)

Antigène: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Épitope: pTyr179

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NGEF est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Homologie: Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human Ephexin-1 around the phosphorylation site of Tyr179

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur NGEF

Antigène: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Autre désignation: Ephexin-1 (NGEF Produits)

Synonymes: anticorps Ephexin-1, anticorps ARHGEF27, anticorps EPHEXIN, anticorps Tims2, anticorps ephexin, anticorps Besh3, anticorps ephexin-1, anticorps neuronal guanine nucleotide exchange factor, anticorps NGEF, anticorps Ngef

Sujet:

Synonyms: Ephexin-1 phospho Y179, p-Ephexin-1 phospho Y179, ARHGEF27, Eph-interacting exchange protein, EPHEXIN, Ephexin 1, Neuronal guanine nucleotide exchange factor, Ngef, NGEF_HUMAN.

Background: EPHEXIN is a 710 amino acid protein that localizes to both the membrane and the cytoplasm and contains one SH3 domain, one PH domain and one DH domain. Expressed at high levels in brain and present at lower levels in lung tissue, EPHEXIN interacts with EphA4 and functions as a guanine nucleotide exchange factor (GEF) that is capable of activating Rho A, Rac 1 and Cdc42 and is thought to play a role in axon guidance and growth cone collapse. EPHEXIN is subject to Src-dependent phosphorylation, an event that increases the GEF activity of EPHEXIN toward Rho A. Human EPHEXIN, which exists as multiple alternatively spliced isoforms, shares a high degree of sequence homology with its mouse counterpart, suggesting a conserved role between species.

ID gène: 25791

Pathways: Neurotrophin Signaling Pathway