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HIC1 anticorps (AA 501-650) (Biotin)

HIC1 Reactivité: Souris WB, ELISA, IHC (fro), IHC (p) Hôte: Lapin Polyclonal Biotin
N° du produit ABIN1700693
  • Antigène Voir toutes HIC1 Anticorps
    HIC1 (Hypermethylated in Cancer 1 (HIC1))
    Épitope
    • 14
    • 9
    • 8
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 501-650
    Reactivité
    • 31
    • 19
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    Souris
    Hôte
    • 41
    • 4
    • 1
    Lapin
    Clonalité
    • 42
    • 4
    Polyclonal
    Conjugué
    • 20
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HIC1 est conjugé à/à la Biotin
    Application
    • 42
    • 22
    • 13
    • 13
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
     Réactivité croisée
    Souris
    Homologie
    Human,Rat,Dog,Cow,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human HIC1
    Isotype
    IgG
    Top Product
    Discover our top product HIC1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    HIC1 (Hypermethylated in Cancer 1 (HIC1))
    Autre désignation
    HIC1 (HIC1 Produits)
    Synonymes
    anticorps zfHIC1, anticorps HIC1, anticorps ZBTB29, anticorps ZNF901, anticorps hic-1, anticorps AA408311, anticorps HIC-1, anticorps hypermethylated in cancer 1, anticorps HIC ZBTB transcriptional repressor 1, anticorps hic1, anticorps HIC1, anticorps Hic1
    Sujet

    Synonyms: Hic 1, Hic-1, Hic1, HIC1_HUMAN, Hypermethylated in cancer 1, Hypermethylated in cancer 1 protein, ZBTB29, Zinc finger and BTB domain-containing protein 29, ZNF901.

    Background: Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing. These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression. HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. Conversely, HIC-1 does not interact with components of the HDAC complex, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain.

    ID gène
    3090
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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