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ZBTB7A anticorps (AA 321-420) (Biotin)

ZBTB7A Reactivité: Humain WB, ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal Biotin
N° du produit ABIN1700719
  • Antigène Voir toutes ZBTB7A Anticorps
    ZBTB7A (Zinc Finger and BTB Domain Containing 7A (ZBTB7A))
    Épitope
    • 14
    • 12
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 321-420
    Reactivité
    • 56
    • 22
    • 17
    • 10
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 56
    • 2
    Lapin
    Clonalité
    • 55
    • 3
    Polyclonal
    Conjugué
    • 28
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ZBTB7A est conjugé à/à la Biotin
    Application
    • 49
    • 19
    • 18
    • 14
    • 14
    • 10
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain
    Homologie
    Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Pokemon
    Isotype
    IgG
    Top Product
    Discover our top product ZBTB7A Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    ZBTB7A (Zinc Finger and BTB Domain Containing 7A (ZBTB7A))
    Autre désignation
    Pokemon/ZBTB7 (ZBTB7A Produits)
    Synonymes
    anticorps ZBTB7A, anticorps FBI-1, anticorps FBI1, anticorps LRF, anticorps ZBTB7, anticorps ZNF857A, anticorps pokemon, anticorps 9030619K07Rik, anticorps 9130006G12Rik, anticorps AI452336, anticorps Lrf, anticorps Pokemon, anticorps Zbtb7, anticorps OCZF, anticorps zinc finger and BTB domain containing 7A, anticorps zinc finger and BTB domain containing 7C, anticorps zinc finger and BTB domain containing 7a, anticorps ZBTB7A, anticorps ZBTB7C, anticorps Zbtb7a
    Sujet

    Synonyms: Factor binding IST protein 1, Factor that binds to inducer of short transcripts protein 1, FBI-1, FBI1, HIV-1 1st-binding protein 1, Leukemia/lymphoma related factor, LRF, Pokemon, TIP21, TTF-I interacting peptide 21, ZBTB7, ZBTB7A, Zinc finger and BTB domain-containing protein 7A, ZBT7A_HUMAN.

    Background: Pokemon, the POK erythroid myeloid ontogenic factor, not only regulates the expression of many genes, but also plays an important role in cell tumorigenesis. To investigate the molecular mechanism regulating expression of the Pokemon gene in humans, its 5'-upstream region was cloned and analyzed. Transient analysis revealed that the Pokemon promoter is constitutive. Deletion analysis and a DNA decoy assay indicated that the NEG-U and NEG-D elements were involved in negative regulation of the Pokemon promoter, whereas the POS-D element was mainly responsible for its strong activity. Electrophoretic mobility shift assays suggested that the NEG-U, NEG-D and POS-D elements were specifically bound by the nuclear extract from A549 cells in vitro. Mutation analysis demonstrated that cooperation of the NEG-U and NEG-D elements led to negative regulation of the Pokemon promoter. Moreover, the NEG-U and NEG-D elements needed to be an appropriate distance apart in the Pokemon promoter in order to cooperate. Taken together, our results elucidate the mechanism underlying the regulation of Pokemon gene transcription, and also define a novel regulatory sequence that may be used to decrease expression of the Pokemon gene in cancer gene therapy.

    ID gène
    51341
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