FZD8 anticorps (Biotin)
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- Antigène Voir toutes FZD8 Anticorps
- FZD8 (Frizzled Family Receptor 8 (FZD8))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FZD8 est conjugé à/à la Biotin
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Frizzled 8
- Isotype
- IgG
- Top Product
- Discover our top product FZD8 Anticorps primaire
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- Indications d'application
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WB: (1:100-1000), IHC-P: (1:100-500)
Optimal working dilution should be determined by the investigator. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C for 12 months.
- Date de péremption
- 12 months
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- Antigène
- FZD8 (Frizzled Family Receptor 8 (FZD8))
- Autre désignation
- Frizzled 8 (FZD8 Produits)
- Synonymes
- anticorps FZ-8, anticorps hFZ8, anticorps FZD8, anticorps Fz-8, anticorps frizzled8, anticorps xfz8, anticorps Xfz8, anticorps frizzled-8, anticorps hfz8, anticorps Fz8, anticorps fzd8, anticorps fz5, anticorps fz8a, anticorps fzc, anticorps wu:fd02c05, anticorps zg05, anticorps ZG06, anticorps Zfz8b, anticorps fz6, anticorps fz8b, anticorps fzA, anticorps ik:tdsubc_1e1, anticorps xx:tdsubc_1e1, anticorps zfzA, anticorps frizzled class receptor 8, anticorps frizzled class receptor 8 S homeolog, anticorps frizzled class receptor 8 L homeolog, anticorps frizzled class receptor 8a, anticorps frizzled class receptor 8b, anticorps FZD8, anticorps fzd8.S, anticorps fzd8, anticorps Fzd8, anticorps fzd8.L, anticorps fzd8a, anticorps fzd8b
- Sujet
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Synonyms: Frizzled 8 seven transmembrane spanning receptor, frizzled 8, seven transmembrane spanning receptor, Frizzled family receptor 8, frizzled homolog 8 Drosophila, Frizzled homolog 8, Frizzled-8, FZ 8, Fz-8, FZ8, FZD 8, FZD8, FZD8_HUMAN, hFZ 8, hFZ8, HGNC4046, Homolog of Drosophila Frizzled 8.
Background: The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted mammalian frizzled-related proteins (FRPs), have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy-terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The cysteine-rich domain of frizzled-8 blocks endogenous Wnts and the effects of Wnt-1 and Wnt-5 on proliferation. The mouse frizzled-8 gene, which encodes a Wnt receptor, is a potent cancer-associated activator of the Beta-catenin-TCF pathway. The frizzled-8 gene contains no introns. Frizzled-8 mRNA has been detected in fetal brain and kidney, and also in adult pancreas, skeletal muscle, kidney and heart. Frizzled is highly expressed in HeLa S3 (cervical uterus cancer) cells and A549 lung cancer cells.
- ID gène
- 8325
- Pathways
- Signalisation WNT
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