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BORA anticorps (AA 31-130) (Biotin)

BORA Reactivité: Humain WB, ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal Biotin
N° du produit ABIN1701167
  • Antigène Voir toutes BORA Anticorps
    BORA (Protein Aurora Borealis (BORA))
    Épitope
    • 14
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 31-130
    Reactivité
    • 44
    • 13
    • 13
    Humain
    Hôte
    • 41
    • 2
    • 1
    Lapin
    Clonalité
    • 44
    Polyclonal
    Conjugué
    • 13
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BORA est conjugé à/à la Biotin
    Application
    • 23
    • 13
    • 13
    • 11
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human BORA
    Isotype
    IgG
    Top Product
    Discover our top product BORA Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    BORA (Protein Aurora Borealis (BORA))
    Autre désignation
    BORA (BORA Produits)
    Synonymes
    anticorps CG6897, anticorps Dmel\\CG6897, anticorps zgc:101616, anticorps C13orf34, anticorps 6720463M24Rik, anticorps AI317232, anticorps RGD1309522, anticorps c13orf34, anticorps C12H13orf34, anticorps aurora borealis, anticorps bora, aurora kinase A activator, anticorps protein aurora borealis, anticorps bora, aurora kinase A activator S homeolog, anticorps bora, anticorps Tsp_06066, anticorps Bora, anticorps BORA, anticorps bora.S
    Sujet

    Synonyms: Aurora borealis, bora, BORA_HUMAN, C13orf34, Chromosome 13 open reading frame 34, FLJ22624, HsBora, Protein aurora borealis, RP11-342J4.2.

    Background: Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.

    ID gène
    79866
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