GUCA1C anticorps (AA 141-209) (HRP)

N° du produit ABIN1711020

Détail du produit anti-GUCA1C anticorps (HRP)

Antigène: GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))

Épitope: AA 141-209

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GUCA1C est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GCAP3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GUCA1C

Antigène: GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))

Autre désignation: GCAP3 (GUCA1C Produits)

Synonymes: anticorps gcap3, anticorps GCAP3, anticorps guanylate cyclase activator 1C, anticorps guca1c, anticorps GUCA1C

Sujet:

Synonyms: GCAP 3, Guanylate cyclase activating photoreceptor 3, Guanylate cyclase activator 1C, Guanylyl cyclase activating protein 3, Guanylyl cyclase-activating protein 3, GUC1C_HUMAN, GUCA1C.

Background: The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating proteins (GCAP). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily and are specifically expressed in retina. GCAP3 (Guanylyl cyclase-activating protein 3), also known as GUCA1C (Guanylate cyclase activator 1C), is a 209 amino acid EF-hand calcium binding protein that is activated by the decrease in calcium from the absorption of light by rhodopsin. Activation of GCAP3 leads to stimulation of guanylate cyclase 1 and 2 (GC1 and GC2), which increases cGMP concentration. Calcium sensitive regulation of GC is essential in recovery of the rod receptor dark state following light exposure. There are two isoforms of GCAP3 that are produced as a result of alternative splicing events.

ID gène: 9626

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction