IQSEC2 anticorps (AA 851-950) (HRP)

N° du produit ABIN1711366

Détail du produit anti-IQSEC2 anticorps (HRP)

Antigène: IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))

Épitope: AA 851-950

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IQSEC2 est conjugé à/à la HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human IQSEC2

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur IQSEC2

Antigène: IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))

Autre désignation: IQSEC2 (IQSEC2 Produits)

Synonymes: anticorps BRAG1, anticorps MRX1, anticorps Brag1, anticorps mKIAA0522, anticorps RGD1562109, anticorps IQ motif and Sec7 domain 2, anticorps IQSEC2, anticorps Iqsec2

Sujet:

Synonyms: BRAG1, IQ mot and SEC7 domain-containing protein 2, IQEC2_HUMAN, Iqsec2, KIAA0522, mKIAA0522, MRX1, RP11-258C19.1.

Background: IQSEC2 is a 1,478 amino acid protein that belongs to the BRAG family and contains one IQ domain, one PH domain and a SEC7 domain. Localizing to the cytoplasm, IQSEC2 is expressed in brain, kidney and small intestine, with weaker levels of expression in placenta, pancreas, ovary, prostate and liver. IQSEC2 is a component of the postsynaptic density at excitatory synapses, and interacts with ARF family members as a guanine nucleotide exchange factor. Through the activation of ARF substrates, IQSEC2 may play a crucial role in cytoskeletal and synaptic organization. The gene encoding IQSEC2 maps to the human X chromosome. Defects to the IQSEC2 gene have been linked to mental retardation X-linked type 1 (MRX1), a condition characterized by decreased intellectual function. IQSEC2 exists as three isoforms due to alternative splicing events.