FNBP1 anticorps (AA 331-430) (HRP)

N° du produit ABIN1712049

Détail du produit anti-FNBP1 anticorps (HRP)

Antigène: FNBP1 (Formin Binding Protein 1 (FNBP1))

Épitope: AA 331-430

Reactivité: Poisson-ballons, Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FNBP1 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Poisson-ballons, Xenopus laevis

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Zebrafish

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FBP17

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur FNBP1

Antigène: FNBP1 (Formin Binding Protein 1 (FNBP1))

Autre désignation: FBP17 (FNBP1 Produits)

Synonymes: anticorps MGC122623, anticorps MGC146466, anticorps FBP17, anticorps 1110057E06Rik, anticorps 2210010H06Rik, anticorps FBP1, anticorps Fbp17, anticorps formin binding protein 1, anticorps formin binding protein 1 L homeolog, anticorps FNBP1, anticorps fnbp1, anticorps Fnbp1, anticorps fnbp1.L

Sujet:

Synonyms: FBP1, FBP17, FNBP1, FNBP1_HUMAN, Formin binding protein 1, Formin binding protein 17, Formin-binding protein 1, Formin-binding protein 17, hFBP17, KIAA0554, MGC126804.

Background: FNBP1 is a 617 amino acid protein that localizes to a variety of locations within the cell, including the cytoplasm, cytoskeleton, lysosome and the cell cortex, and contains one FCH domain, one REM repeat and one SH3 domain. Expressed at high levels in respiratory, reproductive and urinary systems, as well as in brown adipose tissue and epithelial cells of the gastrointestinal tract, FNBP1 interacts with Rho 7 and links the Actin cytoskeleton with Rho 7 signaling, playing a crucial role in membrane tubulation and cytoskeletal reorganization during endocytosis. Additionally, FNBP1, which exists as four alternatively spliced isoforms, enhances Actin polymerization and promotes membrane invagination and the formation of tubules. Chromosomal aberrations in the FNBP1 gene are associated with acute leukemias, suggesting a role for defective FNBP1 in carcinogenesis.

ID gène: 23048