HHATL anticorps (AA 25-125) (HRP)

N° du produit ABIN1712346

Détail du produit anti-HHATL anticorps (HRP)

Antigène: HHATL (Hedgehog Acyltransferase-Like (HHATL))

Épitope: AA 25-125

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HHATL est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HHATL/GUP1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur HHATL

Antigène: HHATL (Hedgehog Acyltransferase-Like (HHATL))

Autre désignation: HHATL/GUP1 (HHATL Produits)

Synonymes: anticorps Gup1, anticorps RGD1311911, anticorps gup1, anticorps oact3, anticorps mboat3, anticorps MGC53261, anticorps mstp002, anticorps MGC89797, anticorps GUP1, anticorps 1110011D13Rik, anticorps C3orf3, anticorps MBOAT3, anticorps MSTP002, anticorps OACT3, anticorps c3orf3b, anticorps gup1b, anticorps im:7145545, anticorps wu:fc04e05, anticorps zgc:154131, anticorps c3orf3a, anticorps gup1a, anticorps zgc:77750, anticorps hedgehog acyltransferase-like, anticorps hedgehog acyltransferase like S homeolog, anticorps hedgehog acyltransferase like, anticorps hedgehog acyltransferase like, b, anticorps hedgehog acyltransferase like, a, anticorps Hhatl, anticorps hhatl.S, anticorps HHATL, anticorps hhatl, anticorps hhatlb, anticorps hhatla

Sujet:

Synonyms: C3orf3, Glycerol uptake/transporter homolog, GUP1, GUP1 glycerol uptake/transporter homolog, Hedgehog acyltransferase like, Hedgehog acyltransferase-like protein, Hhatl, HHATL_HUMAN, KIAA1173, MBOAT3, Membrane bound O acyltransferase domain containing 3, MSTP002, OACT3, Protein-cysteine N-palmitoyltransferase HHAT-like protein.

Background: GUP1 is a 504 amino acid multipass membrane protein of the endoplasmic reticulum that functions as a membrane bound O-acyltransferase. With specific expression in heart, GUP1 negatively regulates amino-terminal palmitoylation of Shh by HHAT, a protein that is required for Shh signaling. Deletion of the gene encoding GUP1 results in higher sensibility to specific sphinogolipid biosynthesis inhibitors and resistance to ergosterol biosynthesis inhibitors, indicating that GUP1 is an essential component in lipid metabolism. Also, GUP1 also seems to be important for cell wall assembly and stability due to evidence in Saccharomyces cerevisiae GUP1 mutants, which exhibit altered plasma membrane lipid composition and membrane potential.

ID gène: 57467

Pathways: Signalisation Hedgehog