Chloride Channel 5 anticorps (AA 1-100)

N° du produit ABIN1713746

Détail du produit anti-Chloride Channel 5 anticorps

Antigène: Chloride Channel 5 (CLCN5)

Épitope: AA 1-100

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Chloride Channel 5 est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Chloride Channel 5/CLC5

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Chloride Channel 5

Antigène: Chloride Channel 5 (CLCN5)

Autre désignation: Chloride Channel 5 (CLCN5 Produits)

Synonymes: anticorps CLCN3, anticorps CLCN5, anticorps clcn5-A, anticorps DKFZp469O2315, anticorps 5430408K11Rik, anticorps ClC-5, anticorps Clc5, anticorps D930009B12Rik, anticorps DXImx42e, anticorps Sfc13, anticorps T25545, anticorps CLC5, anticorps CLCK2, anticorps DENTS, anticorps NPHL1, anticorps NPHL2, anticorps XLRH, anticorps XRN, anticorps hCIC-K2, anticorps CLCN4, anticorps Clcn5, anticorps chloride voltage-gated channel 5, anticorps chloride channel, voltage-sensitive 5 L homeolog, anticorps chloride channel, voltage-sensitive 5, anticorps CLCN5, anticorps clcn5.L, anticorps clcn5, anticorps Clcn5

Sujet:

Synonyms: Chloride channel protein 5, Chloride transporter ClC-5, ClC-5, CLC5, CLCK2, CLCN5, CLCN5_HUMAN, DENTS, H+/Cl- exchange transporter 5, hCIC-K2, NPHL1, NPHL2, XLRH, XRN.

Background: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7q32, 3q28, 4q32, Xp22.3, Xp11.23-p11.22, 1p36 and 16p13, respectively. CLC1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent?s disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC6 and CLC7 are broadly expressed in several tissues including testis, kidney, brain and muscle.