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SUMO2/3 anticorps (AA 21-95)

SUMO2/3 Reactivité: Humain WB, FACS, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1714011
  • Antigène Tous les produits SUMO2/3
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Épitope
    • 15
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 21-95
    Reactivité
    • 48
    • 14
    • 14
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 37
    • 10
    • 1
    Lapin
    Clonalité
    • 29
    • 19
    Polyclonal
    Conjugué
    • 14
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SUMO2/3 est non-conjugé
    Application
    • 41
    • 23
    • 15
    • 14
    • 13
    • 12
    • 10
    • 6
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
     Réactivité croisée
    Humain
    Homologie
    Mouse,Rat,Cow,Horse,Chicken,Rabbit,Zebrafish
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Sumo 2+3
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Autre désignation
    Sumo 2+3 (SUMO2/3 Produits)
    Synonymes
    anticorps SUMO2, anticorps small ubiquitin-like modifier 2, anticorps SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-like, anticorps small ubiquitin-related modifier 2, anticorps SUMO2, anticorps LOC711990, anticorps LOC714892
    Sujet

    Synonyms: HSMT3, MGC117191, OTTHUMP00000115275, OTTHUMP00000115276, OTTHUMP00000115277, Sentrin 2, Small ubiquitin like modier 2, Small ubiquitin like modier protein 3, Small ubiquitin related modier 2, Small ubiquitin related modier 3, SMT3 A, SMT3 B, SMT3 H1, SMT3 H2, SMT3 homolog 1, SMT3 homolog 2, SMT3 homolog, SMT3 suppressor of m two 3 homolog 1, SMT3 suppressor of m two 3 homolog 2 S. cerevisiae, SMT3 suppressor of m two 3 homolog 2, SMT3 suppressor of m two 3 homolog 3 S. cerevisiae, SMT3 suppressor of m two 3 homolog 3, SMT3A, SMT3B, SMT3H1, SMT3H2, Sumo 2, Sumo 3, Sumo2, Sumo3, Suppressor of m two 3 homolog 2, Suppressor of m two 3 homolog 3, Ubiquitin like protein SMT3A, Ubiquitin like protein SMT3B, SUMO2_HUMAN, SUMO3_HUMAN.

    Background: The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer?s disease.

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