ASAH1 anticorps (AA 301-395)
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- Antigène Voir toutes ASAH1 Anticorps
- ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
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Épitope
- AA 301-395
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Reactivité
- Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ASAH1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Réactivité croisée
- Souris
- Homologie
- Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Acid ceramidase subunit beta
- Isotype
- IgG
- Top Product
- Discover our top product ASAH1 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
- Autre désignation
- ASAH1 (ASAH1 Produits)
- Synonymes
- anticorps AC, anticorps ACDase, anticorps ASAH, anticorps PHP, anticorps PHP32, anticorps SMAPME, anticorps 2310081N20Rik, anticorps Asah, anticorps MGC82286, anticorps asah1, anticorps zgc:101637, anticorps ASAH1, anticorps zgc:66026, anticorps N-acylsphingosine amidohydrolase 1, anticorps N-acylsphingosine amidohydrolase (acid ceramidase) 1, anticorps N-acylsphingosine amidohydrolase (acid ceramidase) 1 L homeolog, anticorps N-acylsphingosine amidohydrolase (acid ceramidase) 1a, anticorps Acid ceramidase, anticorps N-acylsphingosine amidohydrolase (acid ceramidase) 1b, anticorps ASAH1, anticorps Asah1, anticorps asah1.L, anticorps asah1a, anticorps asah-1, anticorps asah1b
- Sujet
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Synonyms: AC, ACDase, Acid CDase, Acid ceramidase, Acid ceramidase precursor, Acid ceramidase subunit beta, Acylsphingosine deacylase, ASAH 1, ASAH, ASAH1, ASAH1_HUMAN, FLJ21558, FLJ22079, N acylsphingosine amidohydrolase acid ceramidase 1, N acylsphingosine amidohydrolase 1, N acylsphingosine amidohydrolase, N-acylsphingosine amidohydrolase, PHP, PHP32, Putative 32 kDa heart protein.
Background: Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored, for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.
- ID gène
- 427
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