FZD3 anticorps (AA 121-220)
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- Antigène Voir toutes FZD3 Anticorps
- FZD3 (Frizzled Family Receptor 3 (FZD3))
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Épitope
- AA 121-220
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Reactivité
- Humain, Souris, Rat, Xenopus laevis
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FZD3 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human FZD3/Frizzled 3
- Isotype
- IgG
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease." dans: Experimental and molecular pathology, Vol. 101, Issue 2, pp. 241-248, (2016) (PubMed).
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Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease." dans: Experimental and molecular pathology, Vol. 101, Issue 2, pp. 241-248, (2016) (PubMed).
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- Antigène
- FZD3 (Frizzled Family Receptor 3 (FZD3))
- Autre désignation
- FZD3/Frizzled 3 (FZD3 Produits)
- Synonymes
- anticorps Fz-3, anticorps FZ-3, anticorps fz3, anticorps Xfz3, anticorps frz3, anticorps hfz3, anticorps frz-3, anticorps frizzled3, anticorps frizzled-3, anticorps FZD3, anticorps AU020229, anticorps D930050A07Rik, anticorps Fz3, anticorps fz9, anticorps fzd3, anticorps zg09, anticorps fzd3l, anticorps frizzled class receptor 3, anticorps frizzled class receptor 3 L homeolog, anticorps frizzled class receptor 3a, anticorps frizzled class receptor 3b, anticorps FZD3, anticorps fzd3, anticorps fzd3.L, anticorps Fzd3, anticorps fzd3a, anticorps fzd3b
- Sujet
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Synonyms: Fz-3, Frizzled-3, hFz3, FZD3
Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
- ID gène
- 7976
- UniProt
- Q9NPG1
- Pathways
- Signalisation WNT, Tube Formation
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