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GUCA1B anticorps (AA 21-120)

GUCA1B Reactivité: Humain WB, ELISA, ICC, IF (cc), IF (p), IHC (fro), IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1714375
  • Antigène Voir toutes GUCA1B Anticorps
    GUCA1B (Guanylate Cyclase Activator 1B (Retina) (GUCA1B))
    Épitope
    • 14
    • 8
    • 1
    • 1
    • 1
    AA 21-120
    Reactivité
    • 26
    • 11
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 26
    • 1
    Lapin
    Clonalité
    • 26
    • 1
    Polyclonal
    Conjugué
    • 10
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GUCA1B est non-conjugé
    Application
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Human,Mouse,Rat,Cow,Sheep,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human GCAP2
    Isotype
    IgG
    Top Product
    Discover our top product GUCA1B Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    GUCA1B (Guanylate Cyclase Activator 1B (Retina) (GUCA1B))
    Autre désignation
    GCAP2 (GUCA1B Produits)
    Synonymes
    anticorps GUCA1B, anticorps BC018258, anticorps GCAP2, anticorps GUCA2, anticorps RP48, anticorps guanylate cyclase activator 1B, anticorps guanylate cyclase activator 1B (retina), anticorps GUCA1B, anticorps guca1b, anticorps Guca1b
    Sujet

    Synonyms: GCAP 2, Guanylate Cyclase Activating Protein Photoreceptor 2, Guanylate Cyclase Activator 1B, Guanylin 2, Guanylyl cyclase-activating protein 2, GUC1B_HUMAN, GUCA 2, GUCA1B.

    Background: The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of cGMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90 % similar, consisting of 201 to 205 amino acids and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event. The genes which encode GCAP1 and GCAP2 map to human chromosome 6p21.1.

    ID gène
    2979
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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