CTLA4 anticorps (AA 75-170)

N° du produit ABIN1714514

Détail du produit anti-CTLA4 anticorps

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Épitope: AA 75-170

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CTLA4 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CTLA-4/CD152

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-CTLA4 (ABIN1714514)

Schlößer, Drebber, Kloth, Thelen, Rothschild, Haase, Garcia-Marquez, Wennhold, Berlth, Urbanski, Alakus, Schauss, Shimabukuro-Vornhagen, Theurich, Warnecke-Ebertz, Stippel, Zippelius, Büttner, Hallek et al.: "Immune checkpoints programmed death 1 ligand 1 and cytotoxic T lymphocyte associated molecule 4 in gastric adenocarcinoma. ..." dans: Oncoimmunology, Vol. 5, Issue 5, pp. e1100789, (2016) (PubMed).

Tamaka, Seike, Hagiwara, Sato, Ohtsu: "Histamine suppresses regulatory T cells mediated by TGF-? in murine chronic allergic contact dermatitis." dans: Experimental dermatology, Vol. 24, Issue 4, pp. 280-4, (2015) (PubMed).

Détails sur CTLA4

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Autre désignation: CTLA4 (CTLA4 Produits)

Sujet:

Synonyms: CD, GSE, GRD4, CD152, CTLA-4, IDDM12, CELIAC3, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA4

Background: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

ID gène: 1493

UniProt: P16410

Pathways: Cancer Immune Checkpoints