ALKBH1 anticorps (AA 1-100)

N° du produit ABIN1714649

Détail du produit anti-ALKBH1 anticorps

Antigène: ALKBH1 (AlkB, Alkylation Repair Homolog 1 (ALKBH1))

Épitope: AA 1-100

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALKBH1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ABH1/ALKB

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur ALKBH1

Antigène: ALKBH1 (AlkB, Alkylation Repair Homolog 1 (ALKBH1))

Autre désignation: ABH1/ALKB (ALKBH1 Produits)

Synonymes: anticorps Alkbh, anticorps ABH, anticorps ABH1, anticorps ALKBH, anticorps alkB, anticorps hABH, anticorps 2700073G19Rik, anticorps Abh, anticorps alkB homolog 1, histone H2A dioxygenase, anticorps Alkbh1, anticorps ALKBH1

Sujet:

Synonyms: ABH, ABH1, alkB, AlkB, alkylation repair homolog 1 E. coli, ALKB1_HUMAN, ALKBH, ALKBH1, Alkylated DNA repair protein alkB homolog 1, Alkylation repair homolog 1, Alkylation repair, alkB homolog, Alpha-ketoglutarate-dependent dioxygenase ABH1, DNA lyase ABH1, hABH.

Background: ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumor DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.

ID gène: 8846

Pathways: Réparation de l'ADN