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GAB3 anticorps (AA 31-130)

GAB3 Reactivité: Humain WB, ELISA, ICC, IF (cc), IF (p), IHC (fro), IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1714787
  • Antigène Voir toutes GAB3 Anticorps
    GAB3 (GRB2-Associated Binding Protein 3 (GAB3))
    Épitope
    • 9
    • 9
    • 7
    • 1
    • 1
    AA 31-130
    Reactivité
    • 18
    • 2
    • 1
    Humain
    Hôte
    • 19
    Lapin
    Clonalité
    • 19
    Polyclonal
    Conjugué
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp GAB3 est non-conjugé
    Application
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human GAB3
    Isotype
    IgG
    Top Product
    Discover our top product GAB3 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    GAB3 (GRB2-Associated Binding Protein 3 (GAB3))
    Autre désignation
    GAB3 (GAB3 Produits)
    Synonymes
    anticorps 5930433H21Rik, anticorps GRB2 associated binding protein 3, anticorps growth factor receptor bound protein 2-associated protein 3, anticorps GAB3, anticorps gab3, anticorps Gab3
    Sujet

    Synonyms: Gab3, GAB3_HUMAN, GRB2-associated binder 3, GRB2-associated-binding protein 3, Growth factor receptor bound protein 2-associated protein 3.

    Background: The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (13). Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur (13). This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins (1,4,5). The recruitment of signaling partners to Gab family members is phosphorylation dependent (1,4). Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6,7). The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5).

    ID gène
    139716
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