GHRHR anticorps
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- Antigène Voir toutes GHRHR Anticorps
- GHRHR (Growth Hormone Releasing Hormone Receptor (GHRHR))
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Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GHRHR est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human GHRHR
- Isotype
- IgG
- Top Product
- Discover our top product GHRHR Anticorps primaire
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- Indications d'application
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- GHRHR (Growth Hormone Releasing Hormone Receptor (GHRHR))
- Autre désignation
- GHRHR (GHRHR Produits)
- Synonymes
- anticorps GHRFR, anticorps GRFR, anticorps IGHD1B, anticorps Ghrfr, anticorps lit, anticorps little, anticorps GHRHREC, anticorps GHRH-R, anticorps growth hormone releasing hormone receptor, anticorps GHRHR, anticorps Ghrhr
- Sujet
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Synonyms: GHRFR, GHRH R, GHRH receptor, Ghrhr, GHRHR_HUMAN, GHRHRpsv, GRF R, GRF receptor, GRFR, Growth hormone releasing factor receptor, Growth hormone releasing hormone receptor, Growth hormone-releasing factor receptor, Growth hormone-releasing hormone receptor.
Background: GHRH-R is a seven transmembrane domain protein that localizes to the somatotroph of the pituitary. GHRH-R plays an important role in growth and acts as a high-affinity receptor for GHRH. Binding of GHRH leads to the coupling of GHRH-R to G-protein which stimulates increased adenylyl cyclase activity and the accumulation of cAMP leading to the synthesis and release of growth hormone and somatotroph proliferation. In addition, this signalling pathway may have direct action in fetal/placental development, reproduction and immune function. GHRH and GHRH-R may also play a role in the regulation of non-rapid eye movement sleep (NREMS). The expression of GHRH-R is dependent on the presence of the POU domain factor Pit-1. Mutations in the gene encoding this protein can result in isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, and anterior pituitary hypoplasia (APH).
- ID gène
- 2692
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Hormone Transport, Regulation of Intracellular Steroid Hormone Receptor Signaling, cAMP Metabolic Process
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