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UBD anticorps (AA 55-165)

UBD Reactivité: Souris, Rat WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1714890
  • Antigène Voir toutes UBD Anticorps
    UBD (Ubiquitin D (UBD))
    Épitope
    • 10
    • 9
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 55-165
    Reactivité
    • 49
    • 49
    • 19
    • 2
    • 2
    • 2
    • 1
    Souris, Rat
    Hôte
    • 61
    • 4
    Lapin
    Clonalité
    • 55
    • 10
    Polyclonal
    Conjugué
    • 24
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp UBD est non-conjugé
    Application
    • 47
    • 24
    • 22
    • 21
    • 8
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
     Réactivité croisée
    Souris, Rat
    Homologie
    Human,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Ubiquitin D
    Isotype
    IgG
    Top Product
    Discover our top product UBD Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    UBD (Ubiquitin D (UBD))
    Autre désignation
    Ubiquitin D (UBD Produits)
    Synonymes
    anticorps FAT10, anticorps GABBR1, anticorps UBD-3, anticorps ubiquitin D, anticorps UBD, anticorps Ubd
    Sujet

    Synonyms: FAT10, UBD-3, GABBR1, Ubiquitin D, Diubiquitin, Ubiquitin-like protein FAT10, UBD

    Background: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).

    ID gène
    10537
    UniProt
    O15205
    Pathways
    Ubiquitin Proteasome Pathway
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