GSTP1 anticorps

N° du produit ABIN1724656

Détail du produit anti-GSTP1 anticorps

Antigène: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GSTP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Fonction: GSTP1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human GSTP1 expressed in E. Coli.

Clone: 3F2C2

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-GSTP1 (ABIN1724656)

Lin, Nelson: "Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells." dans: Cancer research, Vol. 63, Issue 2, pp. 498-504, (2003) (PubMed).

Satoh, Itoh, Yamamoto, Tanaka, Hayakari, Ookawa, Yamazaki, Sato, Tsuchida, Hatayama: "Nrf2 transactivator-independent GSTP1-1 expression in "GSTP1-1 positive" single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells." dans: Carcinogenesis, Vol. 23, Issue 3, pp. 457-62, (2002) (PubMed).

Détails sur GSTP1

Antigène: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Autre désignation: GSTP1 (GSTP1 Produits)

Synonymes: anticorps DFN7, anticorps FAEES3, anticorps GST3, anticorps GSTP, anticorps PI, anticorps GST-P, anticorps Gst3, anticorps Gstp, anticorps Gstp2, anticorps gst-Pi, anticorps GstpiB, anticorps glutathione S-transferase P-like, anticorps glutathione S-transferase pi 1, anticorps glutathione S-transferase pi 1 L homeolog, anticorps glutathione S-transferase, pi 1, anticorps LOC100739163, anticorps GSTP1, anticorps Gstp1, anticorps LOC100861197, anticorps gstp1.L

Sujet:

Description: GSTP1 (glutathione-S-transferase, pi 1), also called GST3/DFN7, is a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. GSTP1 act like a tumor suppressor gene, which when inactivated leads to tumor growth, and the -class glutathione S-transferase is commonly inactivated by somatic CpGisland hypermethylation in cancers of the prostate, liver, and breast. Methylation of regulatory sequences at the GSTP1 gene locus is found in the vast majority (>90 % ) of prostate carcinomas and is associated with transcriptional down-regulation.

Aliases: PI, DFN7, GST3, FAEES3

Poids moléculaire: 23kDa

ID gène: 2950

HGNC: 2950

UniProt: P09211

Pathways: Cellular Response to Molecule of Bacterial Origin