KAT5 anticorps
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- Antigène Voir toutes KAT5 Anticorps
- KAT5 (K(lysine) Acetyltransferase 5 (KAT5))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp KAT5 est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC)
- Fonction
- TIP60 Antibody
- Purification
- Ascitic fluid
- Immunogène
- Purified recombinant fragment of human TIP60 expressed in E. Coli.
- Clone
- 3F9
- Isotype
- IgG2b
- Top Product
- Discover our top product KAT5 Anticorps primaire
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- Indications d'application
- ELISA: 1/10000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Patterning chromatin: form and function for H2A.Z variant nucleosomes." dans: Current opinion in genetics & development, Vol. 16, Issue 2, pp. 119-24, (2006) (PubMed).
: "In and out: histone variant exchange in chromatin." dans: Trends in biochemical sciences, Vol. 30, Issue 12, pp. 680-7, (2005) (PubMed).
: "
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Patterning chromatin: form and function for H2A.Z variant nucleosomes." dans: Current opinion in genetics & development, Vol. 16, Issue 2, pp. 119-24, (2006) (PubMed).
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- Antigène
- KAT5 (K(lysine) Acetyltransferase 5 (KAT5))
- Autre désignation
- TIP60 (KAT5 Produits)
- Sujet
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Description: HTATIP (HIV-1 Tat interacting protein TIP60, about 60 kDa) belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure. There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z. Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regulator of transcription and is important for chromosome stability. Several homologous protein complexes, such as SWR-C, TIP60 and SRCAP (mammals), have been shown to catalyze the ATP-dependent exchange of H2A.Z for H2A in the nucleosome. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.
Aliases: TIP60 (HTATIP)
- Poids moléculaire
- 60kDa
- ID gène
- 10524
- HGNC
- 10524
- UniProt
- Q92993
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway
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