KAT5 anticorps

N° du produit ABIN1724672

Détail du produit anti-KAT5 anticorps

Antigène: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KAT5 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Fonction: TIP60 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human TIP60 expressed in E. Coli.

Clone: 3F9

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-KAT5 (ABIN1724672)

Raisner, Madhani: "Patterning chromatin: form and function for H2A.Z variant nucleosomes." dans: Current opinion in genetics & development, Vol. 16, Issue 2, pp. 119-24, (2006) (PubMed).

Jin, Cai, Li, Conaway, Workman, Conaway, Kusch: "In and out: histone variant exchange in chromatin." dans: Trends in biochemical sciences, Vol. 30, Issue 12, pp. 680-7, (2005) (PubMed).

Détails sur KAT5

Antigène: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Autre désignation: TIP60 (KAT5 Produits)

Sujet:

Description: HTATIP (HIV-1 Tat interacting protein TIP60, about 60 kDa) belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure. There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z. Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regulator of transcription and is important for chromosome stability. Several homologous protein complexes, such as SWR-C, TIP60 and SRCAP (mammals), have been shown to catalyze the ATP-dependent exchange of H2A.Z for H2A in the nucleosome. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

Aliases: TIP60 (HTATIP)

Poids moléculaire: 60kDa

ID gène: 10524

HGNC: 10524

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway