F2RL3 anticorps (AA 1-330)

N° du produit ABIN1724706

Détail du produit anti-F2RL3 anticorps

Antigène: F2RL3 (Coagulation Factor II (Thrombin) Receptor-Like 3 (F2RL3))

Épitope: AA 1-330

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp F2RL3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Fonction: PAR4 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of PAR4(aa1-330) expressed in E. Coli.

Clone: 3G9H7

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-F2RL3 (ABIN1724706)

Weller, Dahl, Lohoff, Kampman, Oslin, Dackis, Ferraro, OBrien, Berrettini: "No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence." dans: Psychiatric genetics, Vol. 16, Issue 5, pp. 193-6, (2006) (PubMed).

Gurumurthy, Goswami, Vasudevan, Rangnekar: "Phosphorylation of Par-4 by protein kinase A is critical for apoptosis." dans: Molecular and cellular biology, Vol. 25, Issue 3, pp. 1146-61, (2005) (PubMed).

Xie, Guo: "Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane." dans: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28266-75, (2004) (PubMed).

Kukoc-Zivojnov, Puccetti, Chow, Bergmann, Ruthardt, Hoelzer, Mitrou, Weidmann, Boehrer: "Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells." dans: Experimental hematology, Vol. 32, Issue 7, pp. 649-56, (2004) (PubMed).

Détails sur F2RL3

Antigène: F2RL3 (Coagulation Factor II (Thrombin) Receptor-Like 3 (F2RL3))

Autre désignation: PAR4 (F2RL3 Produits)

Synonymes: anticorps F2RL3, anticorps PAR4, anticorps F2R like thrombin or trypsin receptor 3, anticorps F2R like thrombin/trypsin receptor 3, anticorps coagulation factor II (thrombin) receptor-like 3, anticorps F2RL3, anticorps F2rl3

Sujet:

Description: Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor.

Aliases: PAWR

ID gène: 5074

HGNC: 5074

UniProt: Q96IZ0

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process