TNK1 anticorps (AA 451-560)

N° du produit ABIN1724711

Détail du produit anti-TNK1 anticorps

Antigène: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Épitope: AA 451-560

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TNK1 est non-conjugé

Application: ELISA

Fonction: TNK1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli.

Clone: 1B5G3

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-TNK1 (ABIN1724711)

Azoitei, Brey, Busch, Fulda, Adler, Seufferlein: "Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation." dans: Oncogene, Vol. 26, Issue 45, pp. 6536-45, (2007) (PubMed).

Hoare, Hoare, Smith, Kalmaz, Small, Stratford May: "Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling." dans: Oncogene, Vol. 22, Issue 23, pp. 3562-77, (2003) (PubMed).

Détails sur TNK1

Antigène: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Autre désignation: TNK1 (TNK1 Produits)

Synonymes: anticorps Kos1, anticorps Tnk1a, anticorps Tnk1b, anticorps Ack-like, anticorps tyrosine kinase non receptor 1, anticorps tyrosine kinase, non-receptor, 1, anticorps TNK1, anticorps Tnk1

Sujet:

Description: TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47- kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

Aliases: MGC46193, TNK1

ID gène: 8711

HGNC: 8711

UniProt: Q13470