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C17orf53 anticorps (AA 282-527)

C17ORF53 Reactivité: Humain WB, ELISA, FACS, ICC Hôte: Souris Monoclonal 7A3A9 unconjugated
N° du produit ABIN1724776
  • Antigène Tous les produits C17orf53 (C17ORF53)
    C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))
    Épitope
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 282-527
    Reactivité
    • 31
    • 15
    • 15
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 19
    • 12
    Souris
    Clonalité
    • 19
    • 12
    Monoclonal
    Conjugué
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp C17orf53 est non-conjugé
    Application
    • 24
    • 13
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human C17ORF53 (AA: 282-527) expressed in E. coli.
    Clone
    7A3A9
    Isotype
    IgG2b
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:50, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Styrkarsdottir, Halldorsson, Gretarsdottir, Gudbjartsson, Walters, Ingvarsson, Jonsdottir, Saemundsdottir, Snorradóttir, Center, Nguyen, Alexandersen, Gulcher, Eisman, Christiansen, Sigurdsson, Kong et al.: "New sequence variants associated with bone mineral density. ..." dans: Nature genetics, Vol. 41, Issue 1, pp. 15-7, (2008) (PubMed).

  • Antigène
    C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))
    Autre désignation
    C17ORF53 (C17ORF53 Produits)
    Synonymes
    anticorps chromosome 17 open reading frame 53, anticorps C17orf53
    Sujet
    C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. , , ,
    Poids moléculaire
    69.8 kDa
    ID gène
    78995
    HGNC
    78995
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