ALDH2 anticorps (AA 317-517)

N° du produit ABIN1724795

Détail du produit anti-ALDH2 anticorps

Antigène: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Épitope: AA 317-517

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ALDH2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Fonction: ALDH2 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human ALDH2 (AA: 317-517) expressed in E. Coli.

Clone: 4G6A3

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/150

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-ALDH2 (ABIN1724795)

Zhang, Gong, Zhang, Li, Hu: "Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease." dans: European heart journal, Vol. 33, Issue 13, pp. 1606-14, (2012) (PubMed).

Bae, Kim, Shin, Kim, Shin, Kim, Kim, Yoon: "The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes." dans: Clinical toxicology (Philadelphia, Pa.), Vol. 50, Issue 4, pp. 242-9, (2012) (PubMed).

Détails sur ALDH2

Antigène: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Autre désignation: ALDH2 (ALDH2 Produits)

Synonymes: anticorps aldh2, anticorps aldh2a, anticorps zgc:63786, anticorps MGC80785, anticorps aldh-e2, anticorps aldhi, anticorps aldm, anticorps rf2b, anticorps ALDH-E2, anticorps ALDHI, anticorps ALDM, anticorps Ahd-5, anticorps Ahd5, anticorps aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1, anticorps aldehyde dehydrogenase 2 family (mitochondrial) L homeolog, anticorps aldehyde dehydrogenase 2 family (mitochondrial), anticorps aldehyde dehydrogenase 2, anticorps aldehyde dehydrogenase, anticorps aldehyde dehydrogenase (NAD(+)), anticorps hypothetical protein, anticorps aldehyde dehydrogenase 2, mitochondrial, anticorps aldh2.1, anticorps aldh2.L, anticorps aldh2, anticorps ALDH2, anticorps RHA1_RS43090, anticorps aldH2, anticorps OE_RS03015, anticorps Aldh2

Sujet:

Description: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50 % of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Aliases: ALDM, ALDHI, ALDH-E2

Poids moléculaire: 56.3kDa

ID gène: 217

HGNC: 217

UniProt: P05091