WHSC2 anticorps (AA 280-511)

N° du produit ABIN1724801

Détail du produit anti-WHSC2 anticorps

Antigène: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Épitope: AA 280-511

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp WHSC2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Fonction: WHSC2 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human WHSC2 (AA: 280-511) expressed in E. Coli.

Clone: 6B11H8

Isotype: IgG2b

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-WHSC2 (ABIN1724801)

Kerzendorfer, Hannes, Colnaghi, Abramowicz, Carpenter, Vermeesch, ODriscoll: "Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome." dans: Human molecular genetics, Vol. 21, Issue 10, pp. 2181-93, (2012) (PubMed).

Yung, Narita, Komori, Yamaguchi, Handa: "Cellular dynamics of the negative transcription elongation factor NELF." dans: Experimental cell research, Vol. 315, Issue 10, pp. 1693-705, (2009) (PubMed).

Détails sur WHSC2

Antigène: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Autre désignation: WHSC2 (WHSC2 Produits)

Synonymes: anticorps BcDNA:SD07139, anticorps CG5874, anticorps Dmel\\CG5874, anticorps NELF, anticorps NELF-A, anticorps Whsc2, anticorps fi75f03, anticorps whsc2, anticorps wu:fi75f03, anticorps MGC85474, anticorps WHSC2, anticorps nelfa, anticorps nelf-a, anticorps p/okcl.15, anticorps Whsc2h, anticorps Negative elongation factor A, anticorps negative elongation factor complex member A, anticorps negative elongation factor complex member A L homeolog, anticorps negative elongation factor complex member A, Whsc2, anticorps Nelf-A, anticorps Nelfa, anticorps nelfa, anticorps nelfa.L, anticorps NELFA

Sujet:

Description: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93 % sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Aliases: NELFA, NELF-A, P/OKcl.15

Poids moléculaire: 57.3kDa

ID gène: 7469

HGNC: 7469

Pathways: Chromatin Binding