CD33 anticorps (AA 15-237)

N° du produit ABIN1724812

Détail du produit anti-CD33 anticorps

Antigène: CD33

Épitope: AA 15-237

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD33 est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)

Fonction: CD33 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. Coli.

Clone: 2C6B7

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-CD33 (ABIN1724812)

Deng, Liu, Wang, Tang, Ren, Xu, Ma, Wang, Zhuang, Wang, Chen: "The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer's disease." dans: Human genetics, Vol. 131, Issue 7, pp. 1245-9, (2012) (PubMed).

Schubert, Kellner, Stein, Kügler, Schwenkert, Saul, Mentz, Singer, Stockmeyer, Hillen, Mackensen, Fey: "A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting." dans: mAbs, Vol. 3, Issue 1, pp. 21-30, (2011) (PubMed).

Détails sur CD33

Antigène: CD33

Autre désignation: CD33 (CD33 Produits)

Synonymes: anticorps SIGLEC-3, anticorps SIGLEC3, anticorps p67, anticorps Siglec-3, anticorps gp67, anticorps CD33 molecule, anticorps CD33 antigen, anticorps CD33, anticorps Cd33

Sujet:

Description: The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD)

Aliases: p67, SIGLEC3, SIGLEC-3

Poids moléculaire: 39.8kDa

ID gène: 945

HGNC: 945

UniProt: P20138