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Integrin Alpha2b anticorps (AA 45-149)

CD41 Reactivité: Humain FACS, ELISA, IHC Hôte: Souris Monoclonal 2E10C9 unconjugated
N° du produit ABIN1724822
  • Antigène Voir toutes Integrin Alpha2b (CD41) Anticorps
    Integrin Alpha2b (CD41)
    Épitope
    • 16
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 45-149
    Reactivité
    • 129
    • 37
    • 21
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 83
    • 48
    • 28
    Souris
    Clonalité
    • 110
    • 43
    • 1
    Monoclonal
    Conjugué
    • 62
    • 18
    • 14
    • 12
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Integrin Alpha2b est non-conjugé
    Application
    • 107
    • 46
    • 28
    • 27
    • 22
    • 21
    • 13
    • 13
    • 11
    • 9
    • 8
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)
    Fonction
    ITGA2B Antibody
    Purification
    Ascitic fluid
    Immunogène
    Purified recombinant fragment of human ITGA2B (AA: 45-149) expressed in E. Coli.
    Clone
    2E10C9
    Isotype
    IgG1
  • Indications d'application

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Park, Chung, Lee, Park, Kim, Kim: "Novel and recurrent mutations of ITGA2B and ITGB3 genes in Korean patients with Glanzmann thrombasthenia." dans: Pediatric blood & cancer, Vol. 59, Issue 2, pp. 335-8, (2012) (PubMed).

    Nurden, Fiore, Nurden, Pillois: "Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models." dans: Blood, Vol. 118, Issue 23, pp. 5996-6005, (2011) (PubMed).

  • Antigène
    Integrin Alpha2b (CD41)
    Autre désignation
    ITGA2B (CD41 Produits)
    Sujet

    Description: ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

    Aliases: GT, GTA, CD41, GP2B, HPA3, CD41B, GPIIb, BDPLT2

    Poids moléculaire
    113.4kDa
    ID gène
    3674
    HGNC
    3674
    UniProt
    P08514
    Pathways
    Integrin Complex
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