FGF4 anticorps (AA 62-123)

N° du produit ABIN1724834

Détail du produit anti-FGF4 anticorps

Antigène: FGF4 (Fibroblast Growth Factor 4 (FGF4))

Épitope: AA 62-123

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FGF4 est non-conjugé

Application: ELISA

Fonction: FGF4 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of humanFGF4 (AA: 62-123) expressed in E. Coli.

Clone: 3A12G9

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-FGF4 (ABIN1724834)

Johannesson, Ståhlberg, Ameri, Sand, Norrman, Semb: "FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner." dans: PLoS ONE, Vol. 4, Issue 3, pp. e4794, (2009) (PubMed).

Mayshar, Rom, Chumakov, Kronman, Yayon, Benvenisty: "Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal." dans: Stem cells (Dayton, Ohio), Vol. 26, Issue 3, pp. 767-74, (2008) (PubMed).

Détails sur FGF4

Antigène: FGF4 (Fibroblast Growth Factor 4 (FGF4))

Autre désignation: FGF4 (FGF4 Produits)

Sujet:

Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.

Aliases: HST, KFGF, HST-1, HSTF1, K-FGF, HBGF-5

Poids moléculaire: 22kDa

ID gène: 2249

HGNC: 2249

UniProt: P08620

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance