CD11b anticorps (AA 623-728)

N° du produit ABIN1724905

Détail du produit anti-CD11b anticorps

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Épitope: AA 623-728

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD11b est non-conjugé

Application: ELISA, Immunocytochemistry (ICC)

Fonction: ITGAM Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. Coli.

Clone: 3A10H5

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-CD11b (ABIN1724905)

Rhodes, Fürnrohr, Roberts, Tzircotis, Schett, Spector, Vyse: "The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes." dans: Annals of the rheumatic diseases, Vol. 71, Issue 12, pp. 2028-34, (2012) (PubMed).

Grüger, Reiners, Schnitzler, Brandenburg, Zündorf: "Garenoxacin-induced increase of CD11b expression on human polymorphonuclear neutrophils does not affect phagocytosis and killing of Staphylococcus aureus." dans: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Vol. 17, Issue 2, pp. 291-6, (2011) (PubMed).

Détails sur CD11b

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Autre désignation: ITGAM (ITGAM Produits)

Sujet:

Description: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.

Aliases: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6

Poids moléculaire: 127.1kDa

ID gène: 3684

HGNC: 3684

UniProt: P11215

Pathways: Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation