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CD11b anticorps (AA 623-728)

ITGAM Reactivité: Humain ELISA, ICC Hôte: Souris Monoclonal 3A10H5 unconjugated
N° du produit ABIN1724905
  • Antigène Voir toutes CD11b (ITGAM) Anticorps
    CD11b (ITGAM) (Integrin alpha M (ITGAM))
    Épitope
    • 16
    • 14
    • 8
    • 6
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 623-728
    Reactivité
    • 278
    • 176
    • 72
    • 34
    • 20
    • 19
    • 17
    • 14
    • 11
    • 10
    • 7
    • 4
    • 4
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 159
    • 116
    • 105
    • 2
    • 1
    • 1
    Souris
    Clonalité
    • 287
    • 93
    • 2
    Monoclonal
    Conjugué
    • 126
    • 39
    • 32
    • 29
    • 22
    • 11
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD11b est non-conjugé
    Application
    • 288
    • 88
    • 87
    • 82
    • 65
    • 50
    • 37
    • 23
    • 23
    • 22
    • 14
    • 14
    • 12
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunocytochemistry (ICC)
    Fonction
    ITGAM Antibody
    Purification
    Purified antibody
    Immunogène
    Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. Coli.
    Clone
    3A10H5
    Isotype
    IgG1
    Top Product
    Discover our top product ITGAM Anticorps primaire
  • Indications d'application

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Rhodes, Fürnrohr, Roberts, Tzircotis, Schett, Spector, Vyse: "The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes." dans: Annals of the rheumatic diseases, Vol. 71, Issue 12, pp. 2028-34, (2012) (PubMed).

    Grüger, Reiners, Schnitzler, Brandenburg, Zündorf: "Garenoxacin-induced increase of CD11b expression on human polymorphonuclear neutrophils does not affect phagocytosis and killing of Staphylococcus aureus." dans: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Vol. 17, Issue 2, pp. 291-6, (2011) (PubMed).

  • Antigène
    CD11b (ITGAM) (Integrin alpha M (ITGAM))
    Autre désignation
    ITGAM (ITGAM Produits)
    Sujet

    Description: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.

    Aliases: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6

    Poids moléculaire
    127.1kDa
    ID gène
    3684
    HGNC
    3684
    UniProt
    P11215
    Pathways
    Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
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