CSF1R anticorps (AA 344-497)

N° du produit ABIN1724925

Détail du produit anti-CSF1R anticorps

Antigène: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Épitope: AA 344-497

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CSF1R est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Fonction: CSF1R Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human CSF1R (AA: 344-497) expressed in E. Coli.

Clone: 6B9B9

Isotype: IgG2b

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-CSF1R (ABIN1724925)

Morandi, Barbetti, Riverso, Dello Sbarba, Rovida: "The colony-stimulating factor-1 (CSF-1) receptor sustains ERK1/2 activation and proliferation in breast cancer cell lines." dans: PLoS ONE, Vol. 6, Issue 11, pp. e27450, (2011) (PubMed).

Kitagawa, Gouda, Kirii, Sugiyama, Ishihama, Fujii, Narumi, Akita, Yokota: "Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase." dans: Journal of biochemistry, Vol. 151, Issue 1, pp. 47-55, (2011) (PubMed).

Détails sur CSF1R

Antigène: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Autre désignation: CSF1R (CSF1R Produits)

Synonymes: anticorps AI323359, anticorps CD115, anticorps CSF-1R, anticorps Csfmr, anticorps Fim-2, anticorps Fms, anticorps M-CSF-R, anticorps M-CSFR, anticorps C-FMS, anticorps CSFR, anticorps FIM2, anticorps FMS, anticorps HDLS, anticorps PDGFRB, anticorps MGC89146, anticorps CSF-1-R, anticorps c-fms, anticorps mrfms, anticorps CSF1, anticorps M-CSF, anticorps csf1r, anticorps fms, anticorps panther, anticorps colony stimulating factor 1 receptor, anticorps macrophage colony-stimulating factor receptor, anticorps colony stimulating factor 1 receptor, a, anticorps Csf1r, anticorps CSF1R, anticorps m-csfr, anticorps csf1r, anticorps csf1ra

Sujet:

Description: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.

Aliases: FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R

Poids moléculaire: 108kDa

ID gène: 1436

HGNC: 1436

UniProt: P07333

Pathways: Signalisation RTK, Inositol Metabolic Process, Cell-Cell Junction Organization