Nibrin anticorps (AA 467-615)

N° du produit ABIN1724946

Détail du produit anti-Nibrin anticorps

Antigène: Nibrin (NBN)

Épitope: AA 467-615

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Nibrin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Fonction: NBN Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human NBN (AA: 467-615) expressed in E. Coli.

Clone: 7E4A2

Isotype: IgG2a

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Nibrin (ABIN1724946)

Zuhlke, Johnson, Okoth, Stoffel, Robbins, Tembe, Salinas, Zheng, Xu, Carpten, Lange, Isaacs, Cooney: "Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer." dans: Familial cancer, Vol. 11, Issue 4, pp. 595-600, (2012) (PubMed).

Zheng, Zhang, Jiang, You, Liu, Lu, Zhou: "Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma." dans: Molecular carcinogenesis, Vol. 50, Issue 9, pp. 689-96, (2011) (PubMed).

Détails sur Nibrin

Antigène: Nibrin (NBN)

Autre désignation: NBN (NBN Produits)

Synonymes: anticorps NBN, anticorps AT-V1, anticorps AT-V2, anticorps ATV, anticorps NBS, anticorps NBS1, anticorps P95, anticorps Nbs1, anticorps im:6911679, anticorps zgc:194152, anticorps nibrin, anticorps NBN, anticorps nbn, anticorps Nbn

Sujet:

Description: Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Aliases: ATV, NBS, P95, NBS1, AT-V1, AT-V2

Poids moléculaire: 85kDa

ID gène: 4683

HGNC: 4683

UniProt: O60934

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response