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SHANK3 anticorps (AA 538-626)

SHANK3 Reactivité: Rat WB, IHC, IF, ICC Hôte: Souris Monoclonal S367-51 unconjugated
N° du produit ABIN1741251
  • Antigène Voir toutes SHANK3 Anticorps
    SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
    Épitope
    • 15
    • 10
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 538-626
    Reactivité
    • 43
    • 11
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 26
    • 21
    Souris
    Clonalité
    • 26
    • 21
    Monoclonal
    Conjugué
    • 13
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SHANK3 est non-conjugé
    Application
    • 31
    • 27
    • 22
    • 21
    • 17
    • 13
    • 13
    • 10
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Detects ~190 kDa. Cross-reacts with SHANK1. Does not cross-react with SHANK2.
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Protein G Purified
    Immunogène
    Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3. Mouse: 100% identity (89/89 amino acids identical). Human: 97% identity (87/89 amino acids identical). ~70% identity with SHANK1 and SHANK2.
    Clone
    S367-51
    Isotype
    IgG2a
    Top Product
    Discover our top product SHANK3 Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    1 μg/ml of ABIN1741251 was sufficient for detection of SHANK1/SHANK3 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C
  • Antigène
    SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
    Autre désignation
    SHANK3 (SHANK3 Produits)
    Synonymes
    anticorps DEL22q13.3, anticorps PROSAP2, anticorps PSAP2, anticorps SCZD15, anticorps SPANK-2, anticorps Prosap2, anticorps AI841104, anticorps Shank3b, anticorps SH3 and multiple ankyrin repeat domains 3, anticorps SH3 and multiple ankyrin repeat domains protein 3, anticorps SHANK3, anticorps shank3, anticorps Shank3
    Sujet
    SHANK proteins are scaffolding adaptors that have been shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. SHANK1-3 of the SHANK/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). SHANK recruits betaPIX and PAK to dendritic spines to regulate postsynaptic structure and interacts with ionotropic receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.
    ID gène
    59312
    UniProt
    Q9JLU4
    Pathways
    Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity
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